参考文献

 

参考文献

NM2009菌株について

能美健彦、祖父尼俊雄、小田美光:高感受性サルモネラ・テスター株開発のストラテジー:薬物代謝酵素遺伝子の導入とDNA修復酵素遺伝子の破壊、環境変異研究 15:13-21(1993)

NM2009菌株について及び、NM2009菌株を用いてのumu試験(試験管法)

  1. Yoshimitu Oda ,Hiroshi Yamazaki, Masahiko Watanabe, Takehiko Nohmi,Tsutomu Shimada : Highly sensitive umu test system for the detection of mutagenic nitroarenes in Salmonella typhimurium NM3009 having high O-acetyltransferase and nitroreductase activities , Environmental and Molecular Mutagen, 21: 357-364 (1993)
  2. Yoshimitu Oda ,Hiroshi Yamazaki,Masahiko Watanabe, Takehiko Nohmi,Tsutomu Shimada : Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium stain NM2009 possessing high O-acetyltransferase activity , Mutation Research, 334: 145-156 (1995)

ウムラックATキット総論

斉藤俊光、湯本聡一、中嶋克行、小田美光:変異原性試験試薬キット ウムラックAT(umu試験法)の基礎的検討,医療と検査機器・試薬 27(2):1-9(2004)

umu試験(試験管法)総論

  1. Yoshimitu Oda, Saiichi Nakamura,I.Oki,T.Kato and H.Shinagawa : Evaluation of the new system (umu-test)for the detection of environmental mutagens and carcinogens, Mutation Research,147:219-229(1985)
  2. Yoshimitsu Oda, Kunihiro Funasaka, Masaaki Kitano, Akihiko, Nakama, and Taro Yoshikura Use of a high-throughtput umu-microplatetest system for rapid detection of genotoxicity produced by mutagenic carcinogens and airborne particulate matter, Environmental and Molecular Mutagenesis, 43, 10-19 (2004)
  3. Georg Reifferscheid, Jurgen Heil : Validation of the SOS/umu-test using test results of 486 chemicals and comparison with the Ames test and carcinogenicity data , Mutation Research, 369:129-145(1996)
  4. 小田美光: 続医薬品の開発—医薬品の変異原性・遺伝毒性—, 第11巻, Umuテスト:30-43 (1991)

試験方法

尾花裕孝、吉田善彦、中村清一:umuテストによる食品中の抗変異原性因子の検索、大阪府立公衆衛生研究所報、17:53-59

試料の採取方法

  1. 早津彦哉:変異原の吸着、トキシコロジーフォーラム、6:242-249(1983)
  2. Commoner B.,A.J.Vithayathil and J.I.Henry: Detection of Metabolic Carcinogen Intermediates in Urine of Carcinogen-fed Rats by Means of Bacterial Mutagenesis , Nature ,249:850-852 (1974)

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